Journal of Translational Medicine and Research
Vol. 22, Nr. 1, March 2017
Update on the Assessment of Severity and Management of Chronic Ischaemic Mitral Regurgitation
Dragoş Vinereanu, Andrea O Ciobanu
Leading Article, March 2017
Article DOI: 10.21614/jtmr-22-1-108
Read article Ischaemic mitral regurgitation is a relatively common finding in patients with acute or chronic coronary disease, as a consequence of left ventricular remodelling. Irrespective of its severity, ischaemic mitral regurgitation is an independent predictor of cardiovascular events and death.
In this review, we discuss the current recommendations for a comprehensive evaluation of mitral regurgitation mechanism and severity, using standard and novel imaging techniques, and also the most recent results from randomized trials regarding complex interventional and surgical treatment choic....[more]
Surgical Options in Synchronous Liver Metastases from Colorectal Cancer
Sorin Alexandrescu, Andrei Diaconescu, Irinel Popescu
REVIEW, March 2017
Article DOI: 10.21614/jtmr-22-1-109
Read article Currently, the treatment of liver metastases of colorectal cancer (CRC) requires a multidisciplinary approach and should be individualized for each patient. Liver resection provides 5 years survival rates ranging between 30 and 58% in patients with liver metastases of CRC.
The optimal timing of liver resection, resection of the primary tumor and neoadjuvant chemotherapy has not been fully established, yet, neither for initially resectable synchronous liver metastases, nor for those initially unresectable which could be converted to resectability. Advocates of simultaneous resect....[more]
Personalized and Dynamic Therapy for Breast Cancer: A Preclinical Perspective
Huanrong Lan, Jianfen Gu, Haidi Li, Ketao Jin
REVIEW, March 2017
Article DOI: 10.21614/jtmr-22-1-110
Read article Breast cancer is one of the leading causes of mortality worldwide. Genomic studies have provided key insights into how breast cancer develop, evolve, metastasize, recurrence and respond to treatment. The advance of next-generation sequencing (NGS) and bioinformatics has led to an unprecedented view of the breast cancer genome and its evolution, and made the dynamic monitoring of recurrence and selective evolution of breast cancer during therapy a reality.
Here we illustrate a proposed preclinical strategy of personalized and dynamic therapy for breast cancer based on the technolo....[more]
Optic Neuropathy in Idiopathic Intracranial Hypertension
Corina Merticariu, Florian Balta, Mircea Merticariu, Ramona Barac, Liliana Voinea
REVIEW, March 2017
Article DOI: 10.21614/jtmr-22-1-111
Read article Adult patients who present with papilloedema and symptoms of raised intracranial pressure need urgent multidisciplinary assessment including neuroimaging, to exclude life-threatening causes. Where there is no apparent underlying cause for the raised intracranial pressure, patients are considered to have idiopathic intracranial hypertension (IIH).

Objectives: This review encompasses the newly revised diagnostic criteria for PTCS in adults and children and the role of obesity in the epidemiology, etiology, and management of IIH.Furthermore, this paper tries to offer a pr....[more]
Teaching and Learning and Self-Assessment in Nuclear Hospital (NH) versus Affiliated (AH) Hospitals Surgical Clerkship in the 6th ye....
João Paulo Araújo Teixeira, Carlos Ribeiro, Luís M. Moreira, José Amarante
ORIGINAL PAPER, March 2017
Article DOI: 10.21614/jtmr-22-1-112
Read article Background: the increasing of the numerus clausus becomes difficult to perform surgical clerkship (6th year) in just one hospital. So it became necessary to have the collaboration of Affiliated Hospitals (AH). This research corresponds to the comparative analysis of that clerkship in those institutions.

Methods: A voluntary and anonymous assessment was conducted by 913 (49.3%) of the 1851 students who attended surgical clerkship in the school years 2007-2008 to 2013-2014 in Oporto Medical School. Surveys were collected corresponding to the student's assessment ....[more]
Use of Collagen, PTFE and PRF Membranes in Bone Reconstruction an Experimental and Histomorphometric Study
Ioana Irina Neculae, Vlad Marian Anghelescu, Sabina Andrada Zurac, Octavian Marius Dinca, Cristian George Vladan, Alexandru Bucur
ORIGINAL PAPER, March 2017
Article DOI: 10.21614/jtmr-22-1-113
Read article Bone regeneration techniques cannot be done without barrier membranes, even if horizontal or vertical ridge augmentation and socket ridge preservation is taken into consideration. This study presents a comparison between outcomes of bone regeneration, after producing standardized bone defects followed by covering them with membranes, on an animal experimental model. The study was conducted on 18 New Zeeland rabbits, by creating 2 defects in the left tibial bone of each rabbit: one standardized defect with a diameter of 4 mm, and the second by creating 5 monocortical holes with a smal....[more]
Same Admission Closure of Temporary Bowel Stomas: Feasibility and Outcomes
Mahim Koshariya, Sudesh Sharda, Pramod K Sharma, A Rai, M C Songra
ORIGINAL PAPER, March 2017
Article DOI: 10.21614/jtmr-22-1-114
Read article Background Aim: This pilot study was designed to investigate the feasibility to close protective loop stomas during the same hospital admission based on data on morbidity and mortality, health-related quality of life and healthcare-related costs shortly after the initial operation as well as to find out the causes that delay the closure and to compare the same admission closure with the delayed closure.

Methodology: We created a temporary small bowel stoma due to various pathology and these patients were divided into two groups i.e one with early closure group ....[more]
Liver Fibrosis and Progression of Liver Disease in Patients with Hepatitis Delta - Results from a Retrospective Study in Romania
Oana Săndulescu, Tamer Samir Al Aker, Anca Streinu-Cercel, Adrian Streinu-Cercel
ORIGINAL PAPER, March 2017
Article DOI: 10.21614/jtmr-22-1-115
Read article Introduction: Due to the relatively low prevalence of hepatitis delta in Europe, Romania is one of the main countries in the region that can provide data on long-term prognosis of patients with this condition.

Methods: We performed a retrospective study to assess liver disease progression and to compare non-invasive methods for assessing liver fibrosis in patients with chronic hepatitis B and delta under current active surveillance at the National Institute for Infectious Diseases Prof. Dr. Matei Balasa, Bucharest, Romania.

Results: The study gro....[more]
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March 2017

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Print ISSN: 2392-7232

Online ISSN: 2393-4999

ISSN-L: 2392-7232

Journal of Translational Medicine and Research is indexed in Scopus, CrossRef (DOI: 10.21614/jtmr)