Journal of Translational Medicine and Research
Vol. 22, Nr. 2, June 2017
Idiopathic Intracranial Hypertension and Associated Optic Neuropathy in Pediatric Patients
Corina Merticariu, Florian Balta, Mircea Merticariu, Ramona Barac, Liliana Voinea
REVIEW, June 2017
Article DOI: 10.21614/jtmr-22-2-116
Read article While idiopathic intracranial hypertension (IIH) is more commonly recognized as a disorder of adults, it affects children of all ages and can have distinctive characteristics when presenting in the prepubertal age group. It is characterized by raised intracranial pressure (ICP) in the absence of brain parenchymal lesion, vascular malformations, hydrocephalus, or central nervous system (CNS) infection. The diagnosis is usually confirmed by a high opening pressure of cerebrospinal fluid (CSF) with exclusion of secondary causes of intracranial hypertension.
Objectives: The p....[more]
High Postoperative Tacrolimus Variability Predisposes to Early Pancreas Graft Loss
Mihnea Ioan Ionescu, Avinash Sewpaul, Rodrigo Figueiredo, Jakub Chmelo, Steven Alan White, Derek Michael Manas, Colin Hugh Wilson
ORIGINAL PAPER, June 2017
Article DOI: 10.21614/jtmr-22-2-117
Read article Background: The therapeutic index for tacrolimus (Tac) is relatively narrow and can vary postoperatively in pancreas transplantation (PancTx) recipients secondary to various factors. We hypothesised that intra-patient Tac variability (%Coefficient of Variance; Tac %CoV) after PancTx would influence early patient outcomes.

Methods: 45 pancTx recipients in our centre between 2009-2014 were retrospectively reviewed. The %CoV was calculated using their inpatient Tac levels [(standard deviation Tac trough level mean Tac trough level) x 100]. Patients were then separ....[more]
Assessment of Hyperfibrinolysis in Cirrhotic Patients Undergoing Orthotopic Liver Transplantation. A Retrospective Observational Stu....
Ecaterina Scarlatescu, Ana M Buruiana, Gabriela Droc, Dana R Tomescu
ORIGINAL PAPER, June 2017
Article DOI: 10.21614/jtmr-22-2-118
Read article Introduction: Prophylactic antifibrinolytics are recommended for patients at risk to develop significant hyperfibrinolysis during liver transplantation, identified by the preoperative thromboelastometry. Even with this approach, postreperfusion hyperfibrinolysis is frequent, often leading to increased bleeding and transfusion requirements.The aim of this study was to assess hyperfibrinolysis and to predict postreperfusion hyperfibrinolysis based on preoperative standard coagulation tests (SCTs) and thromboelastometry in liver transplant patients without an indication for antif....[more]
All About Percutaneous Biliary Drainage in Unresectable Cholangiocarcinoma
Mihai Ranete, Mugur Grasu, Radu Dumitru, Gina Rusu, Mihai Toma, Ioana G. Lupescu
ORIGINAL PAPER, June 2017
Article DOI: 10.21614/jtmr-22-2-119
Read article Purpose: The aim of this study is to describe the role of the percutaneous biliary drainage (PTBD) in the managament of patients with hepatic cholangiocarcinoma (CC) and also to assess outcomes and complications after PTBD procedures.

Methods and Materials: 225 consecutive patients with biliary obstruction managed by PTBD were included. All cases were performed by four consultant interventional radiologist between January 2014 and March 2016. Demografic data, patients history, the radiological data base, laboratory test from and following intervention, procedur....[more]
The Salvage Liver Transplantation in the Treatment of Hepatocelullar Carcinoma
Răzvan Tudor Grigorie, Gheorghe Moisă, Irinel Popescu
CASE REPORT, June 2017
Article DOI: 10.21614/jtmr-22-2-120
Read article Hepatocellular carcinoma (HCC) is the fifth most frequent cancer worldwide and in most cases it evolves on a cirrhotic liver, which requires a complex treatment strategy that includes different options. We present the case of a 62 years old patient, suffering from chronic HBV and HDV hepatitis, which was found, in 2011 with a 7 cm HCC located in the sixth segment of the liver and resected. Within less than a year, tumor relapse was detected (multiple nodules in the remaining sixth segment).
Systemic chemotherapy (Sorafenib) started being administered and two TACE procedures were....[more]
Bouveret s Syndrome: An Unusual Cause of Gastric Outlet Obstruction
Mahim Koshariya, Sandesh Sharma, Udipt Shringi, Romil Jain
CASE REPORT, June 2017
Article DOI: 10.21614/jtmr-22-2-121
Read article Bouveret's syndrome is defined as gastric outlet obstruction caused by duodenal impaction of a large gallstone which passes into the duodenal bulb through a cholecystogastric or cholecystoduodenal fistula. It is a rare condition that causes significant morbidity and mortality and often occurs in the elderly with significant comorbidities .
Individual diagnostic and treatment strategies are required for optimal management and outcome. We describe a case of Bouveret's Syndrome in an elderly patient who was managed successfully through surgery.
Current Issue

June 2017

Supplements

Instructions for authors
Online submission
Contact
Print ISSN: 2392-7232

Online ISSN: 2393-4999

ISSN-L: 2392-7232

Journal of Translational Medicine and Research is indexed in Scopus, CrossRef (DOI: 10.21614/jtmr)